Aminosteril N Hepa

Aminosteril N-Hepa 8%

​Amino acid solution for parenteral nutrition of patients with hepatic insufficiency

Categories: ,
  1. Complete and balanced amino acid profile for effective hepatic encephalopathy treatment
  2. High concentration of branched chain AA and reduced concentration of aromatic AA
  3. Low methionine concentration
  4. High arginine concentration
  5. Effective in maintaining a nitrogen balance
  6. Normalization of pathological plasma amino acid levels
  7. Reduced likelihood of metabolically produced toxic amines
  • Normalization of the pathological plasma amino acid levels in patients with hepatic  insufficiency
  • High arginine content to enhance urea production and improve systemic ammonia clearance
  • Helps reducing hyperammonaemia effect and further exposure to hepatic encephalopathy
  • Improves nitrogen balance

Supply of amino acids as part of a parenteral nutrition in  severe forms of hepatic insufficiency with and without  hepatic encephalopathy when oral or enteral nutrition is  impossible or insufficient or contraindicated

8% ,500 ml glass bottle,

1.0 – 1.25 ml/kg body wt/hr (=0.08 – 0.1 g amino acids/kg body wt/hr)

Characteristics

Aminsterile N Hepa

AA gms

40 gm

BCAA

42 %

AAA

2 %

Arginine

13.4 %

Total Nitrogen (g/l/pack)

12.9

Total Kcals/l

320

Osmolarity (mosmol/L)

770

Infusion Rate

1.25 ml/kg body wt/hr

Max.Dosage (ml/kg bw/day)

18.75

Shelf life (months)

36

Route of Adm

Peripheral
  1. Holm E., Striebel JP., Möller P., Hartmann M. Amino aid solution for parenteral nutrition ad for adjunct treatment of encephalopathy in liver cirrhosis. Studies concerning 120 patients. In Metabolism and clinical implications of branched chain amino and ketoacids (Eds Walser M and Williamson JR, Elsevier North Holland, NY, Amsterdam 1981, pp510-518.
  2. Holm E, Striebel JP, Meisinger E, Haux P, Langhans W, Becker HD. Aminosäurengemiche zur parenteralen Ernährung bei Leber-insuffzienz. Infusionstherapie 1978; 5:274-292.
  3. Kato M., Miwa Y., Tajika M., Hiraoka T., Muto Y., Moriwaki H. Preferential use of branch-chain amino acids as an energy substrate in patients with cirrhosis. Intern Med 1998; 37:429-434.
  4. Naylor CD., O’Rourke K., Detsy AS, et al. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. A meta-analysis. Gastroenterology. 1989;97:1033-1042.
  5. Fiene R.,  Holm E., Dietl H., Mezitis N., Schuler A. Parenteral nutrition with amino acids in hepatic insufficiency. Dt Ges Inn Med 1977; 83:533-537.
  6. Freund H., Fischer J. Our experience with F080 in the treatment of hepatic coma in 63 patients. In  Amino acid and ammonia metabolism in hepatic failure. (Ed Holm E). Witzstrock, Baden-Baden-Köln NY, 1982, pp172-183.
  7. Rakette S., Reimann H-J., Fischer M., Bottermann P. Therapeutic influence on hepatic encephalopathy in patients with cirrhosis of the liver using a special amino acid solution: Biochemical and clinical findings. In Hrsg. Aminosären-und Ammoniakstoff-wechsel bei Leberinsuffizienz. (Ed Holm E). Witzstrock, Baden- Baden-Köln NY, 1982, pp203-210.
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  11. Lochs H, Plauth M. Liver cirrhosis: rationale and modalities for nutritional support – the European Society of Parenteral and Enteral Nutrition consensus and beyond. Curr Opin Clin Nutr Metab Care 1999;2:345-349.
  12. Fiaccadori F., Chinelli F., Pedretti G, Sacchini D. Different nutritional approaches in liver cirrhosis: Effects of nitrogen balance: preliminary report. Front. Gastrointest Res. 1984;8:254-265.
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  15. Cerra FB., Cheung NK., Fischer JE., Kaplowitth N., Schiff ER., Dienstag JL., Bower RH., Mabry CD., Leevy CM., Kiernan T. Disease-specific amino acid infusion (F080) in hepatic encephalopathy : a prospective , randomised, double-blind, controlled trial. JPEN 1985;9:288-295.
  16. Rakette S., Fischer M., Reimann HJ., and von Sommoggy S. Effects of special amino acid solutions in patients with liver cirrhosis and hepatic encephalopathy. In Metabolism and clinical implications of branched-chained and amino-and ketoacids. Walser M., Williamson JR (eds). ElsevierlNorth Holland, New York, Amsterdam 1981;419-425.
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